11-29-2013 02:51 AM - edited 11-29-2013 02:51 AM
I have come across similar problems like this a while back when office 2010 originally came out and was removed and office 2007 was then installed.
You haven't mentioned what version of Office you are using or if the problem has just started happening.
I would switch of UAC if enabled and reboot the machine then test if it still doesn't work do a repair of office, if that doesn't work then try disabling any other add-ins that Word has and then try.
There are a few articles if you search the forum or knowledge base for 000000000046 but I couldn't see where it had HRESULT : 80010001
This is a search with various results that may help