There are several ways that you can use Skype from Act! We have several add-on products like DialIT and Call On CRM that will activate Skype directly from Act! Though you need this functionality for Web, so this next option may work:
There is another way, but I haven't tested it, and I'm not really sure of how well it works so YMMV. Here's a link to the Youtube Video of it: http://www.youtube.com/watch?v=R-MAKaBKLZQ
